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The skyline of Barcellona offers always many surprises. One of them is directly connected with our interests.
A special tower stands in a southern residential area neighborhood, this is a popular metropolitan area grown for the workers in the bustling automotive industry of the 60s.
This is the tower of the Hospital Universitari de Bellvitge. We had a quick visit to the 9th floor together with Dr. Pere Cardona Portela IMG_8025.JPG(see photo).
Next to a “pan-optical” stroke unit at the same level of the Neurosurgery ward a special room hosts the “tele ictus” service.
A service active 24/7 for all partner hospitals of Catalunya. This is one of the Telestroke HUB of Barcelona metropolitan area, the other is the Hospital Universitari Vall d’Hebron.
With safe teleconsult techniques an audio-video streaming (see picture) connects the spoke with the hub. This is of help in the decision making process and facilitates the patient dispatchment avoiding futility.
An efficient regional PACS/RIS system support the clinicians for their decisions. The report written by the stroke expert will reach the spoke hospital in real time minimizing the risk of medical errors.
Also mobile devices ara available to guarantee the service from home by the stroke specialists on call. In Bellvitge 1200 patients are admitted each year and thanks to telemedicine 170 patients are centralized for thrombectomy. Every year 350 teleconsults are done with peaks of 3-4 per day.
We leave the “telestroke tower” with a better idea on one of the most exciting challenges for many health care systems: emergency telemedicine.IMG_8028.JPGIMG_8029.JPG

Fare un salto in ospedale con l’auto d’epoca… per ricordarsi che un ictus … sei mesi fa rischiava di portarti via l’autonomia, la memoria e la libertà. Questo è il regalo che Loriano ci ha fatto lo scorso 29 Ottobre. E’ successo al San Giovanni Battista.

OLTRE 17 milioni di persone nel mondo – 200mila solo in Italia – vengono colpite da ictus cerebrale ogni anno (di queste ne muoiono 6 milioni). Senza contare poi che sono in molti quelli che seppur sopravvivono, dovranno convivere con gravi disabilità o con il terrore che l’ictus si ripresenti di nuovo. L’ictus cerebrale nel solo 2016 ha ucciso o reso invalida un’enorme quantità di persone, uomini, donne e persino bambini, rubando 116 milioni di anni di vita. E continua ad essere la seconda causa più probabile di morte nel mondo intero”.

All’ictus (in inglese stroke, che significa “colpo”) viene dedicata ogni anno la Giornata mondiale (29 ottobre) e dal 2006 è stata istituita l’Organizzazione mondiale dell’ictus (World stroke organization, Wso), che coinvolge 85 Paesi nel mondo. Perché l’ictus – molto spesso invalidante – se si conosce, si può prevenire. “Investire in prevenzione oggi non è più solo intelligente, è obbligatorio – sottolinea l’associazione Alt – perché nessun governo avrà le risorse sufficienti per assistere tutti coloro che verranno colpiti da ictus o da un altro evento da trombosi nei prossimi anni. Dipende molto da noi: dobbiamo sapere quali sono le cause, modificare i fattori di rischio modificabili, imparare a riconoscere problemi nel battito del cuore in noi stessi o in chi ci sta accanto. Insomma, dobbiamo riconoscere i sintomi sospetti e agire immediatamente”.

Ricordarsi i sintomi dell’ictus può velocizzarne il riconoscimento, quindi la diagnosi e la sua cura. RAPIDO!


Alza il braccio,

Parla e DOmanda aiuto

queste le parole chiave che possono salvarci.


The SOCRATES study compares ticagrelor versus aspirin for the prevention of major vascular events in patients with acute ischemic stroke or transient ischemic attack [1,2].


SOCRATES (Acute Stroke Or Transient IsChaemic Attack TReated with Aspirin or Ticagrelor and Patient OutcomES) is a global clinical trial involving 9,600 patients who have experienced an acute ischemic stroke or transient ischemic attack (TIA). Annually, 15 million people worldwide suffer a stroke of this type. Ischemic strokes occur as a result of an obstruction of a vessel supplying blood to the brain. A TIA is secondary to a temporary insufficient blood supply to parts of the brain and is often considered a warning sign that a stroke may follow.

SOCRATES is a randomized, parallel group study evaluating the efficacy of ticagrelor compared to aspirin in reducing major vascular events (composite of all-cause mortality, myocardial infarction [MI], and stroke) in patients with acute ischemic stroke (NIHSS ≤ 5) and TIA.

Also announced today is the initiation of THEMIS (Effect of Ticagrelor on Health Outcomes in DiabEtes Mellitus Patients Intervention Study), a global clinical trial involving 17,000 patients with Type 2 diabetes at high risk of cardiovascular (CV) events. Of the 340 million people who suffer from the disease, 90 percent have type 2 diabetes and 50 percent of whom die from CV disease.

“A major goal of treating patients with diabetes is to reduce their cardiovascular risk,” said THEMIS study co-chair Deepak L. Bhatt, MD, MPH, Professor of Medicine at Harvard Medical School and Senior Physician at Brigham and Women’s Hospital.

“THEMIS will allow us to test a bold new strategy in the care of patients with diabetes who are at high risk of myocardial infarction, stroke, and cardiovascular death,” stated THEMIS study co-chair Ph. Gabriel Steg, MD, Professor of Medicine at Université Paris-Diderot and Director of the Coronary Care Unit at Hôpital Bichat.

THEMIS is an event-driven, randomized, parallel group study evaluating the efficacy of long-term treatment with ticagrelor versus placebo for the prevention of major CV events – the composite of CV death, MI or stroke – in patients with Type 2 diabetes without a history of previous MI or stroke but with documented coronary atherosclerosis.

SOCRATES and THEMIS will be monitored by Independent Data Monitoring Committees who will review the safety and efficacy of treatments in these trials. The trials will be conducted in accordance with Good Clinical Practice. Both studies will be posted on in the near future.

AstraZeneca is currently collaborating with over 4,000 clinical investigators in more than 30 countries as part of the PARTHENON program, and has established partnerships with a number of pre-eminent research institutions. Other studies in the PARTHENON program include PEGASUS, studying BRILINTA for secondary prevention in patients with previous myocardial infarction, and EUCLID studying patients with Peripheral Artery Disease.

PARTHENON will provide an unparalleled dataset to build scientific understanding of BRILINTA in a broad a range of atherothrombotic conditions. AstraZeneca has approved more than 100 investigator sponsored studies, which will be starting during the coming year.

BRILINTA is currently not approved for the treatment of patients with ischemic stroke, TIA, peripheral artery disease, or for secondary prevention in patients with a history of previous myocardial infarction.

BRILINTA Indications

BRILINTA is indicated to reduce the rate of thrombotic cardiovascular (CV) events in patients with ACS (unstable angina [UA], non–ST-elevation myocardial infarction [NSTEMI], or ST-elevation myocardial infarction [STEMI]). In PLATO, BRILINTA has been shown to reduce the rate of a combined end point of CV death, myocardial infarction (MI), or stroke compared to clopidogrel. In PLATO, the difference between treatments was driven by CV death and MI with no difference in stroke. In patients treated with an artery-opening procedure known as percutaneous coronary intervention (PCI), BRILINTA reduces the rate of stent thrombosis.

BRILINTA has been studied in ACS in combination with aspirin. Maintenance doses of aspirin above 100 mg decreased the effectiveness of BRILINTA. Avoid maintenance doses of aspirin above 100 mg daily.


1.Giacalone G, Abbas MA, Corea F. Prevention strategies for cardioembolic stroke: present and future perspectives. Open Neurol J. 2010; 4:56-63. doi: 10.2174/1874205X01004020056.

2.Silvestrelli G, Corea F, Micheli S, Lanari A. Clinical pharmacology and vascular risk.Open Neurol J. 2010;4:64-72. doi: 10.2174/1874205X01004020064.

May anti depressants be helpfull in stroke recovery ? also in non depressed subjects ?

Double blind placebo controlled on benefit of prolonged release Levomilnacipran in ischemic stroke recovery. A phase II RCT sponsored by Pierre Fabre Medicament IRPF. First patient enrolled in France. Up to 90 participating centres, six Italian centres will join the project. Stay tuned.


At ESC 2012 Lisbon, everyone’s talking about IST-3 the positive effects on acute ischemic stroke are mostly within 3 hours. But aged subjects may be more likely to be treated now.

INTERACT 2 trial is likely to be soon closed for reaching the enrollement goal.

The ICTUS trial demonstrated NO effects of citicoline in acute stroke.

ESO committees were also renewed.

The famous saxofonit of the E Street Band Clarence Clemons suffered a stroke. As far as we know suffered of a brain hemorrhage a underwent surgery twice before death was declared saturday night. Few weeks ago the popular Italian journalist Lamberto Sposini suffered a major hemorrhagic stroke. Delays in the emergency transport system (as in Rome) and prevention strategies (as in Miami) may be further optimized as widely discussed. While VIP are involved, the mass media interest may trigger the attention of the population on the topic.


Stroke is the second leading cause of death for people above the age of 60, and the fifth leading cause in people aged 15 to 59. Stroke also attacks children, including newborns.  Each year, nearly six million people die from stroke. In fact, stroke is responsible for more deaths every year than those attributed to AIDS, tuberculosis and malaria put together – three diseases which have set the benchmark for successful public health advocacy, capturing the attention of the world’s media and which consequently has provoked world leaders, governments and many sectors of civil society to act. by WSO

Every six seconds, regardless of age or gender –
someone somewhere will die from stroke.

This, however, is more than a public health statistic. These are people, who at one time, were someone’s sister, brother, wife, husband, daughter, son, partner, mother, father… friend. They did exist and were loved. Behind the numbers are real lives. The World Stroke Organization (WSO) is calling for urgent action to address the silent stroke epidemic by launching the “One in Six” campaign on World Stroke Day, 29 October.

The objective of the campaign is to put the fight against stroke front and center on the global health agenda. The “One in Six” theme was selected by leaders of the WSO to highlight the fact that in today’s world, one in six people worldwide will have a stroke in their lifetime. Everyone is at risk and the situation could worsen with complacency and inaction.





Is now visible to the public the Spread portal for Italian Guidelines in Stroke management. The idea is to develop a “real time” tool to update guidelines. The site is not available for normal users just for faculty members.

January 2019
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